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HowShorted

How shorted is Spyre Therapeutics, Inc.? SYRE

#354most shorted US stockof 3,805 ranked stocks, more shorted than 90%

13.76%
of shares outstanding reported short · settlement date 15 Sep 2026
vs previous report
+0.31
5 reports (~10 weeks)
−1.95
days to cover
11.58
Aggregate net short position time series for Spyre Therapeutics, Inc.

Markers along the chart's base: ▲ results announced (an 8-K reporting results was filed) ▲ quarterly or annual report filed. Dates are SEC filing dates; hover a point to see events since the previous settlement.

Days to cover

FINRA's own figure: reported shares short divided by the stock's average daily trading volume, published alongside each settlement. It expresses the short position in days of typical trading rather than as a percentage of the company; the two can move differently.

Aggregate net short position time series for Spyre Therapeutics, Inc. days to cover

Short interest around results

For each results announcement (an 8-K reporting results, by its SEC filing date), the FINRA settlement before it and the first one after. Settlements fall twice a month, so the two figures can sit up to a month apart and much else changes in between: this shows what was reported, not why.

Reported short interest before and after each results announcement
Results filedSettlement beforeSettlement afterChange
4 Aug 202613.77% 31 Jul 202613.33% 14 Aug 2026−0.44
5 May 202614.07% 30 Apr 202614.30% 15 May 2026+0.23
13 Apr 202613.29% 31 Mar 202614.86% 15 Apr 2026+1.57
19 Feb 202612.56% 13 Feb 202612.71% 27 Feb 2026+0.15
4 Nov 202515.99% 31 Oct 202516.06% 14 Nov 2025+0.07
14 Oct 202523.94% 30 Sep 202522.17% 15 Oct 2025−1.77
5 Aug 202521.32% 31 Jul 202521.83% 15 Aug 2025+0.51
8 May 202524.41% 30 Apr 202520.37% 15 May 2025−4.04

Fails to deliver

The SEC's fails-to-deliver figure for SYRE: the aggregate net balance of shares that failed to be delivered at each settlement date, published by the SEC twice a month and shown here verbatim for the trailing window. A balance is not a daily flow, and a fail has many ordinary causes; the SEC says it cannot guarantee the accuracy of the data. See what fails to deliver are and the largest balances today.

Latest balance
9
14 Sep 2026
Highest in window
207,327
22 Jun 2026
Days with a balance
86
Window
16 Sep 2025 to 14 Sep 2026
Aggregate net short position time series for Spyre Therapeutics, Inc. fails to deliver

Source: U.S. Securities and Exchange Commission, fails-to-deliver data (public domain). Only settlement days with a positive balance appear; the largest balance in the window was 207K shares.

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Sector: Healthcare · By year: 2019 · 2020 · 2021 · 2022 · 2023 · 2024 · 2025 · 2026

History

Full reported short interest history
Settlement dateShort %Change
15 Sep 202613.76%+0.31
31 Aug 202613.45%+0.12
14 Aug 202613.33%−0.44
31 Jul 202613.77%−0.63
15 Jul 202614.40%−1.31
30 Jun 202615.71%+1.18
15 Jun 202614.53%−0.01
29 May 202614.54%+0.24
15 May 202614.30%+0.23
30 Apr 202614.07%−0.79
15 Apr 202614.86%+1.57
31 Mar 202613.29%+0.56
13 Mar 202612.73%+0.02
27 Feb 202612.71%+0.15
13 Feb 202612.56%−0.30
30 Jan 202612.86%−0.12
15 Jan 202612.98%−2.02
31 Dec 202515.00%−0.23
15 Dec 202515.23%+0.85
28 Nov 202514.38%−1.68
14 Nov 202516.06%+0.07
31 Oct 202515.99%−6.18
15 Oct 202522.17%−1.77
30 Sep 202523.94%+1.12
15 Sep 202522.82%−0.50
29 Aug 202523.32%+1.49
15 Aug 202521.83%+0.51
31 Jul 202521.32%−1.22
15 Jul 202522.54%+0.19
30 Jun 202522.35%+1.49
13 Jun 202520.86%+0.83
30 May 202520.03%−0.34
15 May 202520.37%−4.04
30 Apr 202524.41%+1.56
15 Apr 202522.85%+0.76
31 Mar 202522.09%+1.15
14 Mar 202520.94%+1.45
28 Feb 202519.49%+0.19
14 Feb 202519.30%−0.60
31 Jan 202519.90%+0.45
15 Jan 202519.45%+0.12
31 Dec 202419.33%+0.62
13 Dec 202418.71%+1.48
29 Nov 202417.23%+1.60
15 Nov 202415.63%−0.61
31 Oct 202416.24%−0.32
15 Oct 202416.56%−0.46
30 Sep 202417.02%−0.16
13 Sep 202417.18%+0.52
30 Aug 202416.66%+0.83
15 Aug 202415.83%−3.56
31 Jul 202419.39%−3.09
15 Jul 202422.48%+3.14
28 Jun 202419.34%+7.32
14 Jun 202412.02%+0.66
31 May 202411.36%+0.15
15 May 202411.21%+9.69
31 Aug 20231.52%−0.03
15 Aug 20231.55%+0.79
15 Jun 20230.76%+0.25
31 May 20230.51%−0.15
15 May 20230.66%−0.04
28 Apr 20230.70%−0.46
14 Apr 20231.16%+0.13
31 Mar 20231.03%+0.11
28 Feb 20230.92%−0.27
15 Feb 20231.19%+0.33
31 Jan 20230.86%−0.12
13 Jan 20230.98%−0.65
30 Dec 20221.63%−0.02
15 Dec 20221.65%+0.32
30 Nov 20221.33%−0.59
15 Nov 20221.92%+0.93
31 Oct 20220.99%+0.14
14 Oct 20220.85%−0.27
30 Sep 20221.12%+0.07
15 Sep 20221.05%−0.27
31 Aug 20221.32%−0.59
15 Aug 20221.91%+0.26
29 Jul 20221.65%−3.53
15 Jun 20225.18%+1.16
31 May 20224.02%−0.32
13 May 20224.34%−0.20
29 Apr 20224.54%+0.16
14 Apr 20224.38%+0.28
31 Mar 20224.10%+1.27
15 Mar 20222.83%−0.03
28 Feb 20222.86%−0.35
15 Feb 20223.21%+1.47
31 Jan 20221.74%+0.28
14 Jan 20221.46%−0.21
31 Dec 20211.67%−0.23
15 Dec 20211.90%+0.51
30 Nov 20211.39%+0.05
15 Nov 20211.34%−0.06
29 Oct 20211.40%+0.06
15 Oct 20211.34%−0.36
30 Sep 20211.70%+0.10
15 Sep 20211.60%−0.45
31 Aug 20212.05%−0.05
13 Aug 20212.10%−0.07
30 Jul 20212.17%−0.77
15 Jul 20212.94%−1.29
30 Jun 20214.23%−0.35
15 Jun 20214.58%+0.19
28 May 20214.39%+0.25
14 May 20214.14%−0.09
30 Apr 20214.23%−0.32
15 Apr 20214.55%+0.21
31 Mar 20214.34%+0.14
15 Mar 20214.20%+0.42
26 Feb 20213.78%+0.04
12 Feb 20213.74%−0.14
29 Jan 20213.88%−0.12
15 Jan 20214.00%+0.15
31 Dec 20203.85%+0.17
15 Dec 20203.68%−2.17
30 Nov 20205.85%+0.04
13 Nov 20205.81%−0.78
30 Oct 20206.59%−0.22
15 Oct 20206.81%+0.44
30 Sep 20206.37%+0.38
15 Sep 20205.99%−0.11
31 Aug 20206.10%+2.11
14 Aug 20203.99%+0.86
31 Jul 20203.13%+0.93
15 Jul 20202.20%−0.35
30 Jun 20202.55%+1.51
15 Jun 20201.04%−0.38
29 May 20201.42%+0.60
15 May 20200.82%−0.05
30 Apr 20200.87%+0.06
15 Apr 20200.81%−0.12
31 Mar 20200.93%−0.08
13 Mar 20201.01%+0.29
28 Feb 20200.72%+0.10
14 Feb 20200.62%−0.22
31 Jan 20200.84%+0.12
15 Jan 20200.72%+0.02
31 Dec 20190.70%+0.02
13 Dec 20190.68%−0.19
29 Nov 20190.87%−0.04
15 Nov 20190.91%−0.10
31 Oct 20191.01%−0.27
15 Oct 20191.28%–

Newest first. Scroll inside the table for earlier dates, back to 15 Oct 2019.

Frequently asked questions

How shorted is Spyre Therapeutics, Inc. right now?
13.76% of Spyre Therapeutics, Inc.'s (SYRE) shares outstanding were reported short for settlement date 15 Sep 2026, per FINRA's consolidated short interest report. That makes it the 354th most shorted US stock, out of 3,805 we rank.
What does this number include?
FINRA member firms must report their short positions in all US equities twice a month; FINRA consolidates them per security. We divide that official share count by the company's shares outstanding from its SEC filings. This is the regulatory figure, not a daily estimate.
Why does it only update twice a month?
US short interest is reported for settlement on the 15th and the last business day of each month, and FINRA publishes the consolidated figures about nine business days later. That cadence is set by regulation; no daily official figure exists.
Is this SYRE's short float?
No. This is short interest as a percentage of shares outstanding, the count in the company's SEC filings. "Short float" divides the same FINRA short count by the public float, which excludes closely held shares, so it comes out higher for the same company. We publish no float estimates: the float is not a regulatory figure.
What is SYRE's days to cover?
11.58 days for settlement date 15 Sep 2026: FINRA's own short interest ratio, the reported shares short divided by average daily trading volume. It is published in the same FINRA file and shown verbatim; we hold no volume data ourselves.
Which funds are short?
US public short interest is aggregate-only: individual short sellers are not named. Only some EU markets publish named positions.